Yes, you can get a price from Home Depot for the labor and materials, using Andersen products.
The difference between them, in my opinion, is everything. The Andersen will fit properly, look better, last longer, preform better and give you a sense of pride that the other guys can't come anywhere near. And, If your house settles or moves, the Andersen is built to be adjustable to compensate for the movement.
It may sound like I'm a little prejudiced. In my world there is nothing to compare with Andersen products.