Ouch!
Make sure you have enough unused outlets and a way of capping the ones that go bad... Hardly my favorite system....
You may want to look at this link for alternatives to the Home Run System such as the Trunk & Branch and for larger homes the Trunk & Branch with Remote Manifolds...
http://www.toolbase.org/pdf/designguides/pex_designguide.pdf
With the Home Run System there is a huge amount of tubing used and in a larger home long waits for hot water to arrive at each fixture. Recirculation loops are not possible as well....
You may also want to hire a repipe expert to do the drops and get it all done at once, we have our ways of doing things with very little additional damage to walls and ceilings....