I have a long span for the bottom horiz members of my roof trusses in one large room and so there is a crack in the ceiling drywall that opens and closes with time as these boards sag.
A wall there won't look good so sometime I'll go up there and try to reinforce those two-bys.
I'd still look for a gap at the top of the wall before messing with it.
It can't hurt, and if there is no gap the studs may be under compression which means they are bearing some load.
Another option would be to remove every other stud and see what happens.