i have had this request from several folks wanting to make one large room out of the two secondary bedrooms. like kok328 said, if it runs parallel with the joists you should be ok. if you have factory made trusses and someone says, yes you can because you have trusses, be careful. i have seen trusses get lax over years of sitting on a wall and after that wall is removed, they relax an inch or two. this means downward and a cracked line in your sheetrock. stick your head up in the scuttle hole and see if you have custom built rafters or trusses. if you can get in the attic to where you want to take the wall out, look it over. what is on top of that wall? if you are not familiar with scooting around in the attic, get a pro. if you have a chance to get a couple of estimates, do so, and listen and pay attention to what the people say. thanks, budro