A supply and a return in this bedroom is the way to go.
Now,in order to give some proper advice we need some info; what size is this Bedroom? LXWXH. What is the size of the EXTERIOR walls that will border this Bedroom? is there insulation in these exterior walls? what is the R value?
Since hot air rises, it is better to have both the supply low at floor level. The return should also be on an opposite wall, and as far away from the supply as possible.
Post back with the sizes,etc, and we can give some more exact info.