Our house is a 1000 sq foot ranch with a 500 ft Family Room Addition built on a slab.
to get supply heat and a/c into the room, I had to run an 8"supply duct in my crawl space upt to my attic, a distance of 25 feet.
Off of that I have 4- 6x10" vents on the perimeter walls that are fed by a 6"...