An airless sprayer that pumps the paint through a hose to a nozzle won't care what direction it is spraying. The ones with a paint cup may run into challenges when the paint in the cup is below a half a cup depending on which way the pick up lays. You may be able to bend the pick-up hose so it is pulling from the part of the cup facing down when spraying up.Most sprayers look like they are designed for horizontal use. Does anyone have overhead experience with them?
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