To a small extent, yes. And for the holes without hardware cloth, mice will be coming in. Note to self: staple h/w cloth. For that 900 SF (130,000 sq. inches) floor, maybe 6 sq. inches out of the 130 thousand. And this is above whatever the code-approved cutouts for the ducts & water pipes are doing. Figure at least 1 sq. inch for each. It's a tradeoff. New floor every time your sink/dishwasher leaks or marginally increasing the chances of a house fire spreading from a basement with few sources of ignition. Do the numbers, Neal. You'd be surprised at how many opponents get deflated when confronted with facts.